36 a novel

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Village No 36

Author : Amrita Pritam
ISBN : STANFORD:36105111316357
Genre : Indic fiction (English)
File Size : 75. 52 MB
Format : PDF
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Hotel Angeline

Author : Seattle7Writers
ISBN : 9781453212318
Genre : Fiction
File Size : 23. 71 MB
Format : PDF, Mobi
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Thirty-six of the most interesting writers in the Pacific Northwest came together for a week-long marathon of writing live on stage. The result? Hotel Angeline, a truly inventive novel that surprises at every turn of the page. Something is amiss at the Hotel Angeline, a rickety former mortuary perched atop Capitol Hill in rain-soaked Seattle. Fourteen-year-old Alexis Austin is fixing the plumbing, the tea, and all the problems of the world, it seems, in her landlady mother’s absence. The quirky tenants—a hilarious mix of misfits and rabble-rousers from days gone by—rely on Alexis all the more when they discover a plot to sell the Hotel. Can Alexis save their home? Find her real father? Deal with her surrogate dad’s dicey past? Find true love? Perhaps only their feisty pet crow, Habib, truly knows. Provoking interesting questions about the creative process, this novel is by turns funny, scary, witty, suspenseful, beautiful, thrilling, and unexpected.

Reality 36

Author : Guy Haley
ISBN : 9780857661470
Genre : Fiction
File Size : 44. 66 MB
Format : PDF
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SOMETHING IS AMISS IN THE RENEGADE DIGITAL REALM OF REALITY 36. Richards - a Level 5 AI with a PI fetish - and his partner, a decommissioned German military cyborg, are on the trail of a murderer, but the killer has hidden inside an artificial reality. Richards and Klein must stop him before he becomes a god - for the good of all the realms.

36 Arguments For The Existence Of God

Author : Rebecca Goldstein
ISBN : 9780307378903
Genre : Fiction
File Size : 60. 25 MB
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From the author of The Mind-Body Problem: a witty and intoxicating novel of ideas that plunges into the great debate between faith and reason. At the center is Cass Seltzer, a professor of psychology whose book, The Varieties of Religious Illusion, has become a surprise best seller. Dubbed “the atheist with a soul,” he wins over the stunning Lucinda Mandelbaum—“the goddess of game theory.” But he is haunted by reminders of two people who ignited his passion to understand religion: his teacher Jonas Elijah Klapper, a renowned literary scholar with a suspicious obsession with messianism, and an angelic six-year-old mathematical genius, heir to the leadership of an exotic Hasidic sect. Hilarious, heartbreaking, and intellectually captivating, 36 Arguments explores the rapture and torments of religious experience in all its variety.

36 Yalta Boulevard

Author : Olen Steinhauer
ISBN : 1429940131
Genre : Fiction
File Size : 59. 78 MB
Format : PDF, Kindle
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Olen Steinhauer's acclaimed first two novels, The Bridge of Sighs and The Confession, have garnered thus far an Edgar nomination, an Anthony nomination, a Macavity nomination, a Historical Dagger nomination, and five starred reviews. Now he takes this superb literary series set in a nameless Eastern European country into the 1960s. State Security Officer Brano Sev is the secretive member of the homicide department of the capital's people's militia. No one else quite trusts him, but it is part of his job to do what the authorities ask, no matter what. So when he gets an order to travel to the village of his birth in order to interrogate a potential defector, he goes. When a man turns up dead shortly after he arrives, and Brano is framed for the murder, he assumes this is part of the plan and allows it to run its course. But when the plan leads him into exile in Vienna, he finally begins to ask questions. In fact, in The Man from Yalta Boulevard, a tour-de-force political thriller from Olen Steinhauer, Comrade Brano Sev learns that loyalty to the cause might be the biggest crime of all.

The 36 Hour Day

Author : Nancy L. Mace
ISBN : 9781421422237
Genre : Family & Relationships
File Size : 44. 91 MB
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The 36-Hour Day is the definitive dementia care guide.

Brca1 Associated Protein Brcc36 A Novel Target For Breast Cancer Therapy

Author :
ISBN : OCLC:505429196
Genre :
File Size : 27. 15 MB
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Since tumor cells in general are genomically unstable and have defects in DNA damage responses, it has been proposed that targeting DNA repair pathways may lead to a therapeutic index in tumor cells over "normal" cells. Previous studies have demonstrated that BRCC36 is over-expressed in the vast majority of invasive breast cancers and that depletion of BRCC36 sensitizes breast cancer cells to IR via the BRCA1 DNA repair pathway. Therefore, we hypothesize that abrogation of BRCC36 will sensitize breast tumors to the DNA-damage based therapies. To test this hypothesis, we will utilize an antibody (anti-HER2)-protamine based siRNA delivery system to selectively deplete BRCC36 in breast tumor xenografts. This cancer cell-specific or "smart" therapeutic approach should improve the targeting of breast tumor cells while reducing non-specific toxicity. The proposed studies will clearly establish BRCC36 as a novel therapeutic target to enhance the efficacy of radiation and chemotherapy which elicit DNA damage. As the antibody is currently being developed for ImmunoPET imaging trials in breast cancer patients, clinical translation of successful preclinical results of our antibody-P/siRNA conjugates could be rapidly achieved.

Scandalous Behavior

Author : Stuart Woods
ISBN : 9780698195059
Genre : Fiction
File Size : 51. 26 MB
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Stone Barrington is back, in fine form, in the newest thriller from the #1 New York Times–bestselling author. After a series of nonstop adventures, Stone Barrington is eager for some peace and quiet in a rustic British setting. But no sooner does he land in England than he’s beset by an outrageous demand from a beautiful lady, and an offer he can’t refuse. Unfortunately, Stone quickly learns that his new acquisition comes with some undesired strings attached—namely, a deadly mystery involving the complex relationships of the local gentry, and a relentless adversary who raises the stakes with every encounter. Stone’s restful country vacation is looking like yet another troublesome situation, but with his tireless aplomb—and the help of a few friends—he is more than up to the challenge. From the Hardcover edition.

Making Money

Author : Terry Pratchett
ISBN : 9781407034010
Genre : Fiction
File Size : 73. 8 MB
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'Whoever said you can't fool an honest man wasn't one' The Royal Bank is facing a crisis, and it’s time for a change of management. Who would not to wish for that job? It's a job for life. But, as former con-man Moist von Lipwig is learning, the life is not necessarily for long. The Chief Cashier is almost certainly a vampire. There's something nameless in the cellar (and the cellar itself is pretty nameless), it turns out that the Royal Mint runs at a loss, and people actually want to know where the money’s gone. A 300 year old wizard is after his girlfriend, he's about to be exposed as a fraud, but the Assassins Guild might get him first. In fact lot of people want him dead Oh. And every day he has to take the Chairman for walkies. Everywhere he looks he's making enemies. What he should be doing is . . . Making Money!

Brcc36 A Novel Subunit Of A Brca1 E3 Ubiquitin Ligasa Complex Candidates For Brca3

Author :
ISBN : OCLC:227951989
Genre :
File Size : 66. 12 MB
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Breast cancer is a genetically heterogeneous disease, and multiple genes remain to be identified among BRCAl and BRCA2 mutation-negative breast cancer-prone families. We believe that a valid approach to identify genetic factors that contribute to breast cancer risk is to evaluate genes coding for proteins that interact with BRCAl in a multiple protein complex. We have recently found one such candidate, referred to as BRCC36. We have reported a profound increase in BRCC36 expression in breast tumors. Furthermore, our studies have defined BRCC36 as a direct regulator of BRCA1 activation and nuclear foci formation in response to IR in a number of breast cancer cell lines. Our results have found that down-regulation of BRCC36 expression impairs homologous recombination repair (HRR) . Therefore, our data suggest that DNA repair pathway activated in response to IR and appears to sensitize breast cancer cells to IR-induced apoptosis. Importantly, we found that BRCC36 mutated in the germline of a cancer-prone family and may increase the risk of developing breast cancer. Overall, aberrant expression or mutation of BRCC36 genes in breast tumors may lead to disruption of the normal function of BRCAl and contribute to the development of breast cancer.

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